A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications.
Molavi B, Rassouli N, Bagwe S, Rasouli N.
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA.
Vasc Health Risk Manag. 2007;3(6):967-73. PMID: 18200815

The rising incidence of obesity and insulin resistance to epidemic proportions has closely paralleled the surge in the prevalence of diabetes and outpaced therapeutic advances in diabetes prevention and treatment. Current evidence points to obesity induced oxidative stress and chronic inflammation as the common denominators in the evolution of insulin resistance and diabetes. Of all the hypoglycemic agents in the pharmacological arsenal against diabetes, thiazolidinediones, in particular pioglitazone, as well as metformin appear to have additional effects in ameliorating oxidative stress and inflammation; rendering them attractive tools for prevention of insulin resistance and diabetes. In addition to their hypoglycemic and lipid modifying properties, pioglitazone and metformin have been shown to exert anti-oxidative and anti-inflammatory effects in vascular beds, potentially slowing the accelerated atherosclerosis in diabetes, which is the major cause of morbidity and mortality in the affected population. The combination of pioglitazone and metformin would thus appear to be an effective pharmacological intervention in prevention and treatment of diabetes. Finally, this review will address the currently available evidence on diabetic cardiomyopathy and the potential role of combination therapy with pioglitazone and metformin.

Thiazolidinediones review

pubmed search

wiki thiazolidinediones
--> --> -->
<type 'exceptions.ImportError'>
Python 2.7.9: /usr/bin/python
Wed Oct 26 20:15:48 2016

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www-mass/thiazolidinediones.com/relatedArticles/relatedArticlesBLTC.py in ()
     68 #import bio/pubmed modules
     69 sys.path.append('biopython') #need to have this module in nearby folder if moving around servers, add this line to find it
=>   70 from Bio import Entrez
     71 from Bio import Medline
     72 Entrez.email = "pythonPubmed@circuitblue.com"
Bio undefined, Entrez undefined

<type 'exceptions.ImportError'>: No module named Bio
      args = ('No module named Bio',)
      message = 'No module named Bio'